- Belikova NA, Glumac A, Rafikov R, Jiang J, Greenberger JS, Kagan VE, Bayir H.
Radioprotection by short-term oxidative preconditioning: Role of manganese superoxide dismutase.
FEBS Lett. 2009 Oct 13. [Epub ahead of print]. PMID: 19822147.
- Tyurina YY, Tyurin VA, Kapralova VI, Amoscato AA, Epperly MW, Greenberger JS, Kagan VE.
Mass-spectrometric characterization of phospholipids and their hydroperoxide derivatives in vivo: effects of total body irradiation.
Methods Mol Biol. 2009;580:153-83. PMID: 19784599 [PubMed - in process]
- Kagan VE, Wipf P, Stoyanovsky D, Greenberger JS, Borisenko G, Belikova NA, Yanamala N, Samhan Arias AK, Tungekar MA, Jiang J, Tyurina YY, Ji J, Klein-Seetharaman J, Pitt BR, Shvedova AA, Bayir H.
Mitochondrial targeting of electron scavenging antioxidants: Regulation of selective oxidation vs random chain reactions.
Adv Drug Deliv Rev. 2009 Aug 27. [Epub ahead of print] PMID: 19716396
- Belikova NA, Tyurina YY, Borisenko G, Tyurin V, Samhan Arias AK, Yanamala N, Furtmüller PG, Klein-Seetharaman J, Obinger C, Kagan VE.
Heterolytic reduction of fatty acid hydroperoxides by cytochrome c/cardiolipin complexes: antioxidant function in mitochondria.
J Am Chem Soc. 2009 Aug 19;131(32):11288-9. PMID: 19627079
- Belikova NA, Jiang J, Stoyanovsky DA, Glumac A, Bayir H, Greenberger JS, Kagan VE.
Mitochondria-targeted (2-hydroxyamino-vinyl)-triphenyl-phosphonium releases NO* and protects mouse embryonic cells against irradiation-induced apoptosis.
FEBS Lett. 2009 May 7. [Epub ahead of print] PMID: 19427865
- Tyurin VA, Tyurina YY, Jung MY, Tungekar MA, Wasserloos KJ, Bayir H, Greenberger JS, Kochanek PM, Shvedova AA, Pitt B, Kagan VE.
Mass-spectrometric analysis of hydroperoxy- and hydroxy-derivatives of cardiolipin and phosphatidylserine in cells and tissues induced by pro-apoptotic and pro-inflammatory stimuli.
J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 13. [Epub ahead of print] PMID: 19328050
- Murray AR, Kisin E, Leonard SS, Young SH, Kommineni C, Kagan VE, Castranova V, Shvedova AA.
Oxidative Stress and Inflammatory Response in Dermal Toxicity of Single-walled Carbon Nanotubes.
Toxicology. 2009 Mar 29;257(3):161-71. Epub 2008 Dec 30. PMID: 19150385
- Kagan VE, Bayir HA, Belikova NA, Kapralov O, Tyurina YY, Tyurin VA, Jiang J, Stoyanovsky DA, Wipf P, Kochanek PM, Greenberger JS, Pitt B, Shvedova AA, Borisenko G.
Cytochrome C/Cardiolipin Relations in Mitochondria: A Kiss of Death.
Free Radic Biol Med. 2009 Mar 11. [Epub ahead of print] PMID: 19285551
- Shurin MR, Potapovich AI, Tyurina YY, Tourkova IL, Shurin GV, Kagan VE.
Recognition of Live Phosphatidylserine-Labeled Tumor Cells by Dendritic Cells: A Novel Approach to Immunotherapy of Skin Cancer.
Cancer Res. 2009 Mar 10. [Epub ahead of print] PMID: 19276376
- Konduru NV, Tyurina YY, Feng W, Basova LV, Belikova NA, Bayir H, Clark K, Rubin M, Stolz D, Vallhov H, Scheynius A, Witasp E, Fadeel B, Kichambare PD, Star A, Kisin ER, Murray AR, Shvedova AA, Kagan VE.
Phosphatidylserine Targets Single-walled Carbon Nanotubes to Professional Phagocytes in Vitro and in Vivo. PLoS ONE.
2009;4(2):e4398. Epub 2009 Feb 9. PMID: 19198650
- Godoy LC, Muńoz-Pinedo C, Castro L, Cardaci S, Schonhoff CM, King M, Tórtora V, Marín M, Miao Q, Jiang JF, Kapralov A, Jemmerson R, Silkstone GG, Patel JN, Evans JE, Wilson MT, Green DR, Kagan VE, Radi R, Mannick JB.
Disruption of the M80-Fe Ligation Stimulates the Translocation of Cytochrome C to the Cytoplasm and Nucleus in Nonapoptotic Cells.
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2653-8. Epub 2009 Feb 5. PMID: 19196960
- Bayir H, Adelson PD, Wisniewski SR, Shore P, Lai Y, Brown D, Janesko-Feldman KL, Kagan VE, Kochanek PM.
Therapeutic Hypothermia Preserves Antioxidant Defenses after Severe Traumatic Brain Injury in Infants and Children.
Crit Care Med. 2008 Dec 26; [Epub ahead of print]. PMID: 19114918
- Jitkaew S, Witasp E, Zhang S, Kagan VE, Fadeel B.
Induction of Caspase- and Reactive Oxygen Species-Independent Phosphatidylserine Externalization in Primary Human Neutrophils: Role in Macrophage Recognition and Engulfment.
J Leukoc Biol. 2008 Dec 23; [Epub ahead of print]. PMID: 19106181
- Maki RA, Tyurin VA, Lyon RC, Hamilton RL, Dekosky ST, Kagan VE, Reynolds WF.
Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer's disease.
J Biol Chem. 2008 Dec 5. [Epub ahead of print] PMID: 19059911
- Borisenko, G. G. Kapralov, A. A. Tyurin, V. A. Maeda, A. Stoyanovsky, D. A. and Kagan, V. E.
Molecular Design of New Inhibitors of Peroxidase Activity of Cytochrome c/Cardiolipin Complexes: Fluorescent Oxadiazole-Derivatized Cardiolipin.
Biochemistry, November 2008.
- Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS.
Starving Neurons Show Sex Difference in Autophagy.
J Biol Chem. 2008 Nov 25. [Epub ahead of print] PMID: 19036730
- Tyurin VA, Tyurina YY, Feng W, Mnuskin A, Jiang J, Tang M, Zhang X, Zhao Q, Kochanek PM, Clark RS, Bayir H, Kagan VE.
Mass-Spectrometric Characterization of Phospholipids and their Primary Peroxidation Products in Rat Cortical Neurons During Staurosporine-Induced Apoptosis.
J Neurochem. 2008 Nov 6. [Epub ahead of print] PMID: 19014376
- Kagan VE, Bayir A, Bayir H, Stoyanovsky D, Borisenko GG, Tyurina YY, Wipf P, Atkinson J, Greenberger JS, Chapkin RS, Belikova NA.
Mitochondria-targeted disruptors and inhibitors of cytochrome c/cardiolipin peroxidase complexes: A new strategy in anti-apoptotic drug discovery.
Mol Nutr Food Res. 2008 Oct 31. PMID: 18979502 - Allen BL, Kichambare PD, Gou P, Vlasova II, Kapralov AA, Konduru N, Kagan VE, Star A.
Biodegradation of Single-Walled Carbon Nanotubes through Enzymatic Catalysis.
Nano Lett. 2008 Nov;8(11):3899-903. Epub 2008 Oct 28. PMID: 18954125
- Bayir H, Kagan VE.
Bench-to-bedside review: Mitochondrial injury, oxidative stress and apoptosis - there is nothing more practical than a good theory.
Crit Care. 2008 Feb 18;12(1):206 [Epub ahead of print] PMID: 18341705
- Huang Z, Jiang J, Tyurin VA, Zhao Q, Mnuskin A, Ren J, Belikova NA, Feng W, Kurnikov IV, Kagan VE.
Cardiolipin deficiency leads to decreased cardiolipin peroxidation and increased resistance of cells to apoptosis.
Free Radic Biol Med. 2008 Mar 13; [Epub ahead of print] PMID: 18375209
- Jiang J, Belikova NA, Hoye AT, Zhao Q, Epperly MW, Greenberger JS, Wipf P, Kagan VE.
A mitochondria-targeted nitroxide/hemigramicidin s conjugate protects mouse embryonic cells against gamma irradiation.
Int J Radiat Oncol Biol Phys. 2008 Mar 1; 70 ( 3 ): 816-25. PMID: 18262096
- Stoyanovsky DA, Vlasova II, Belikova NA, Kapralov A, Tyurin V, Kagan VE.
Activation of NO donors in mitochondria: Peroxidase metabolism of (2-hydroxyamino-vinyl)-triphenyl-phosphonium by cytochrome c releases NO and protects cells against apoptosis.
FEBS Lett. 2008 Feb 5; [Epub ahead of print] PMID: 18258194
- Tyurina YY, Tyurin VA, Epperly MW, Greenberger JS, Kagan VE.
Oxidative lipidomics of gamma-irradiation-induced intestinal injury.
Free Radic Biol Med. 2008 Feb 1; 44 ( 3 ): 299-314. Epub 2007 Sep 6. PMID: 18215738
- Hoye AT, Davoren, JE, Wipf P, Fink MP, Kagan, VE.
Targeting mitochondria.
Acc Chem Res. 2008 Jan; 41 ( 1 ): 87-97. PMID: 18193822
- Kisin ER, Murray AR, Keane MJ, Shi XC, Schwegler-Berry D, Gorelik O, Arepalli S, Castranova V, Wallace WE, Kagan VE, Shvedova AA.
Single-walled carbon nanotubes: geno- and cytotoxic effects in lung fibroblast V79 cells.
J Toxicol Environ Health A. 2007 Dec; 70 ( 24 ): 2071-9. PMID: 18049996
- Shvedova, A.A., Fabisiak, J.P., Kisin, E.R., Murray, A., Roberts, J., Antonini, J., Kommineini, C., Reynolds, J., Barchwosky, A., Castranova, V., and Kagan, V.E.
Sequential exposure to carbon nanotubes and bacteria enhances pulmonary inflammation and infectivity.
Am. J. Respir. Cell Molec. Biol., 2007 Dec 20. PMID: 18096873.
- Kapralov AA, Kurnikov IV, Vlasova II, Belikova NA, Tyurin VA, Basova LV, Zhao Q, Tyurina YY, Jiang J, Bayir H, Vladimirov YA, Kagan VE.
The Hierarchy of Structural Transitions Induced in Cytochrome c by Anionic Phospholipids Determines Its Peroxidase Activation and Selective Peroxidation during Apoptosis in Cells.
Biochemistry. 2007 Nov 16; [Epub ahead of print]. PMID: 18004876
- Fink MP, Macias CA, Xiao J, Tyurina YY, Delude RL, Greenberger JS, Kagan VE, Wipf P.
Hemigramicidin-TEMPO conjugates: novel mitochondria-targeted antioxidants.
Crit Care Med. 2007 Sep;35(9 Suppl):S461-7. PMID: 17713394
- Belikova NA, Jiang J, Tyurina YY, Zhao Q, Epperly MW, Greenberger J, Kagan VE.
Cardiolipin-specific peroxidase reactions of cytochrome C in mitochondria during irradiation-induced apoptosis.
Int J Radiat Oncol Biol Phys. 2007 Sep 1;69(1):176-86. PMID: 17707271
- Belikova NA, Vladimirov YA, Osipov AN, Kapralov AA, Tyurin VA, Potapovich MV, Basova LV, Peterson J, Kurnikov IV, Kagan VE.
Peroxidase Activity and Structural Transitions of Cytochrome c Bound to Cardiolipin-Containing Membranes.
Biochemistry, 45(15):4998-5009, 2006 PMID: 16605268
- Vlasova II, Tyurin VA, Kapralov AA, Kurnikov IV, Osipov AN, Potapovich MV, Stoyanovsky DA, Kagan VE.
Nitric oxide inhibits peroxidase activity of cytochrome c/cardiolipin complex and blocks cardiolipin oxidation.
J Biol Chem. 281(21):14554-62, 2006 PMID: 16543234
- Kagan VE, Tyurina YY, Tyurin VA, Konduru NV, Potapovich AI, Osipov AN, Kisin ER, Schwegler-Berry D, Mercer R, Castranova V, Shvedova AA.
Direct and indirect effects of single walled carbon nanotubes on RAW 264.7 macrophages: Role of iron.
Toxicol Lett. 165(1):88-100. 2006 PMID: 16527436
- Ramirez RJ, Hubel CA, Novak J, Dicianno JR, Kagan VE, Gandley RE.
Moderate Ascorbate Deficiency Increases Myogenic Tone of Arteries from Pregnant but Not Virgin Ascorbate-Dependent Rats.
Hypertension, 47(3):454-60, 2006 PMID: 16432038
- H. Bayir, B. Fadeel, M.J. Palladino, E. Witasp, I. V. Kurnikov, Y.Y. Tyurina, V.A. Tyurin, A. A. Amoscato, J. Jiang, P. M. Kochanek, S.T. DeKosky, J. S. Greenberger, A.A. Shvedova, V.E. Kagan.
Apoptotic interactions of cytochrome c: redox flirting with anionic phospholipids within and outside of mitochondria.
Biochim.Biophys.Acta – Bioenergetics, 1757(5-6):648-59, 2006 PMID: 16740248
- Epperly MW, Tyurina YY, Nie S, Niu YY, Zhang X, Kagan V, Greenberger JS.
MnSOD-plasmid liposome gene therapy decreases ionizing irradiation-induced lipid peroxidation of the esophagus.
In Vivo. 19(6): 997-1004, 2006PMID: 16277013
- Tyurina YY, Kapralov AA, Jiang J, Borisenko GG, Potapovich AI, Sorokin A, Kochanek PM, Graham SH, Schor NF, Kagan VE.
Oxidation and cytotoxicity of 6-OHDA is mediated by reactive intermediates of COX-2 overexpressed in PC12 cells.
Brain Res., 1093(1):71-82, 2006 PMID: 16712820
- Costacou T, Virella G, Fried L, Zgibor J, Evans RW, Kagan VE, and Orchard TV.
Antioxidants and coronary artery disease among individuals with type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study.
J. Diabet.Complic, 2006 (in press) PMID: 17070445
- Gong H, Singh SV, Singh SP, Mu Y, Lee YJ, Saini SPP, Toma D, Ren S, Kagan VE, Day BW, Zimniak P, and Xie W.
Orphan nuclear receptor PXR sensitizes oxidative stress responses in transgenic mice and cancerous cells.
Molec. Endocrinol. 20(2):279-90, 2006 PMID: 16195250
- St Croix CM, Leelavaninchkul K, Watkins SC, Kagan VE, Pitt BR.
Nitric oxide and zinc homeostasis in acute lung injury.
Proc Am Thorac Soc. 2(3): 236-242, 2005 PMID: 16222044
- Stoyanovsky DA, Tyurina YY, Tyurin VA, Anand D, Mandavia DN, Gius D, Ivanova J, Pitt B, Billiar TR, Kagan VE.
Thioredoxin and Lipoic Acid Catalyze the Denitrosation of Low Molecular Weight and Protein S-Nitrosothiols.
J.Am.Chem.Soc., 2005
PMID: 16277524
- Liang Q, Smith AD, Pan S, Tyurin VA, Kagan VE , Hastings TG, Schor NF.
Neuroprotective effects of TEMPOL in central and peripheral nervous system models of Parkinson's disease.
Biochem Pharmacol. 2005 Sep 3PMID: 16144694
- Wipf P, Xiao J, Jiang J, Belikova NA, Tyurin VA, Fink MP, and Kagan VE.
Mitochondrial Targeting of Selective Electron Scavengers: Synthesis and Biological Analysis of Hemigramicidin-TEMPO Conjugates.
J.Am.Chem.Soc., 127(36):12460-12461, 2005 PMID: 16144372
- Mi Z, Hong B, Mirnics ZK, Tyurina YY, Kagan VE, Liang Y, Schor NF.
Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2.
Cancer Chemother Pharmacol. 1-11, 2005 PMID: 16001169
- Yishak, AA, Costacou, T, Virella, G, Zgibor, J, Fried, L, Walsh, M, Evans, RW, Lopes-Virella, M, Kagan, VE, Otvos, J, Orchard, TJ
Novel predictors of overt nephropathy in subjects with type 1 diabetes. A nested case control study from the Pittsburgh Epidemiology of Diabetes Complications (EDC) cohort.
Nephrol. Dialysis Transplant., 2005 (in press) PMID: 16144851
- Kagan VE, Tyurin VA, Jiang J, Tyurina YY, Ritov VB, Amoscato AA, Osipov AN, Belikova NA, Kapralov AA, Kini V, Vlasova II, Zhao Q, Zou M, Di P, Svistunenko DA, Kurnikov IV, Borisenko GG.
Cytochrome c acts as a cardiolipin oxygenase required for release of pro-apoptotic factors.
Nature Chem Biol., 1, 223-232, 2005 PMID: 16408039
- Tyurina YY, Nylander KD, Mirnics ZK, Portugal C, Yan C, Zaccaro C, Saragovi HU, Kagan VE, Schor NF.
The intracellular domain of p75NTR as a determinant of cellular reducing potential and response to oxidant stress.
Aging Cell, 4(4):187-196, 2005 PMID: 16026333
- Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson IJ, Potapovich AI, Tyurina YY, Gorelik, O, Arepalli S, Schwegler-Berry D, Hubbs AF, Antonini J, Evans DE, Ku, B-K, Ramsey D, Maynard A, Kagan VE, Castranova V, Baron P.
Unusual inflammatory and fibrogenic pulmonary responses to single walled carbon nanotubes in mice.
Amer. J. Physiol: Lung, 2005. PMID: 15951334
- Serinkan. BF, Gambelli F, Potapovich AI, Babu H, Di Giuseppe M, Ortiz LA, Fabisiak JP and Kagan VE.
Apoptotic cells quench reactive oxygen and nitrogen species and modulate TNF-a/TGF-b1 balance in activated macrophages: involvement of phosphatidylserine-dependent and –independent pathways.
Cell Death & Differentation. 12(8):1141-1144, 2005
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